Showing posts with label neuroscience. Show all posts
Showing posts with label neuroscience. Show all posts

Israeli Remedies for a Longer Life



Israelis have the 8th longest life-expectancy in world according to the latest World Health Organization figures.  Israeli medical treatments and devices are extending lives all over the world.  Here are some of the recent Israeli news items relating just to the areas of cancer, cardiology, neuroscience and diabetes.

I am confident that most readers in their lifetimes will see an end to the deadly effect of the majority of today’s cancers and can be proud that Israeli scientists will be major contributors to this achievement. For example, the UK’s National Health Service just has approved the funding of patients receiving the pioneering melanoma (skin cancer) treatment developed by Professor Jacob Schachter of the Sheba hospital in Tel Hashomer.   Meanwhile in the States, surgeons at Mercy Medical Center at Cedar Rapids, Iowa, have reported that MarginProbe from Israel’s Dune Medical has reduced the number of repeat breast-cancer operations by 75%.  And many aggressive brain tumors can now be cured using Novocure’s electrode treatment, invented by Israeli Professor Yoram Palti.



Leukemia’s days are numbered thanks to pipeline treatments such as Astarabine from Israel’s BioSight.and BL-8040 from Israel’s Bioline Rx.  And Israel’s Gamida Cell reported good results from US trials of its NiCord blood cancer treatment.  Finally, Weizmann Institute’s groundbreaking prostate cancer treatment has now been approved by Israel’s Ministry of Health and is being administered to patients at Beilinson Hospital.

But prevention is better than cure, so I was pleased to read that researchers at the Hebrew University of Jerusalem and Israel’s Technion Institute have developed enhanced micro-emulsion liquids that produce a powerful antioxidant anti-cancer protection protein called Nrf2.

It warms my heart to read that so many cardiology treatments and innovations have been developed by Israelis. UK medical journal The Lancet reported the first one-hour implants of the interatrial shunts from Israel’s V-Wave administered into 10 Canadian patients suffering poor left ventricular function, who were then discharged home next morning.  Surgeons performing a multicenter clinical trial of the laser system and unique catheters from Israel’s Eximo successfully unblocked the arteries of 20 patients with peripheral artery disease (PAD) -  some of whom otherwise required bypass surgery or leg amputation.

Scientists at Israel’s Technion Institute have even trained cardiac cells to beat, using mechanical stimuli that do not come into contact with the cells, which could lead to development of more effective pacemakers.  At Tel Aviv University, Professor Tal Dvir unveiled his remote-controlled, bionic heart patch, which researchers say could become a revolutionary alternative to heart transplants for patients whose hearts have been damaged by heart attacks or cardiac disease. 

https://www.youtube.com/watch?v=EZ0bz-r8lEE 


Again, prevention of heart disease would avoid the need for the above treatments and devices, so let’s wish good luck to Israel’s Lycored for its award-winning supplement Cardiomato that lowers oxidized LDL cholesterol and reduces systolic blood pressure.  And perhaps the best news is that new Israeli Education Ministry guidelines prohibit selling or serving of sweets, snacks, and sugary or fatty foods to Israeli school and kindergarten students.  They must now be offered healthier substitutes such as low-fat spreadable cheeses, avocado, whole-wheat pasta and bread, fruit and vegetables.

In the field of Neuroscience, nearly 660,000 people have viewed the video that showed Haifa’s Rambam Medical Center surgeons curing an Israeli woman of Parkinson’s using the focused ultrasound brain surgery of Israel’s Insightec.  And the communication device for ALS and other "Locked in" patients from Israel’s EyeControl won its inventors £32,000 of funding thanks to public votes in the International on-line competition "The Venture".  Israelis should certainly have no problem sleeping thanks to Israeli startup 2breathe Technologies, which has developed a sensor and smartphone app to induce users to breathe slower, relax and fall asleep.  And Israel’s Itamar Medical has reported that 60 international hospitals have now adopted its Total Sleep Solution which treats Sleep Apnea – a known cause of heart attacks.

https://www.youtube.com/watch?v=-WkmqMUIEJ8 


Diabetics will be interested to know that researchers at the Hebrew University of Jerusalem have discovered that the gene p16 enhances insulin production and have partly reversed diabetes in lab tests.  Further down the treatment pipeline, Israeli biotech Oramed had success in the Phase IIb study of its oral insulin capsule, designed to replace injected delayed-release insulin.  Meanwhile, Israel’s Frutarom – developers of Portusana, an extract of the herb purslane - have confirmed its positive effects on blood sugar levels in adults with Type 2 Diabetes.  Finally, type 2 diabetes may be preventable, thanks to a behavioral analytics engine and risk meter developed by Israel’s Sweetch.

https://www.youtube.com/watch?v=KENZRUpeAds 


What is really astounding is that these Israeli developments (and many more) all occurred during the last 3 months.  I haven’t even got room to include the areas of fighting infections, autoimmune diseases and life-saving medical devices.  I’ll report on those on another occasion.

Wishing you good health from Israel.

Michael Ordman writes a free weekly newsletter containing positive news stories about Israel.
For a free subscription, email a request to michael.goodnewsisrael@gmail.com


Right Down to the Wire



The excitement of living in the Start-up Nation can be electric.  You can often feel the buzz from highly charged Israeli entrepreneurs developing their latest wired and wireless innovative products.  You never know, until the last moment, what new life-changing Israeli devices and discoveries are going to be announced. This week I wanted to share some of the latest news that is literally coming over the wire almost every day in the Jewish State.

Regular readers of this blog know that I like to begin with medical news items.  Acwire from Israel’s MediValve is a unique guide-wire tool that has just received European and FDA approval. It helps cardiologists perform the extremely difficult task of implanting heart valves at the exact required spot, thus saving thousands of lives.  In the US, 60,000 deaths from pressure ulcers (bedsores) can also be prevented if more hospitals follow the lead of those installing the MAP (Monitor Alert Protect) system from Israel’s Wellsense. A pressure-sensing mat alerts nurses to reposition patients regularly. 


The wiring of the brain is still a mystery. But as Dr Ofer Yizhar of Israel’s Weizmann Institute explains, the new neuroscience of optogenetics examines light-specific activation or suppression of neurons in the brain.  It could help us understand memory problems, schizophrenia and autism.  Moving further down the body, the Israel transplant center has announced that over 200 patients no longer need to be wired up to dialysis machines thanks to kidney transplants.  Last year 90,000 Israelis signed new ADI organ donor cards, bringing the total of registered holders to 787,087.

They say that all successful entrepreneurs started small.  So it is handy that Yissum, the Research and Development Company of the Hebrew University of Jerusalem, has developed micro-sized electrical circuit wiring from low-cost oxidation-resistant copper nano-inks.  They replace the expensive silver inks that make up circuits in RFID-tags, solar cells, sensors and electrodes for displays.  While we are talking small, Tel Aviv hosts NanoIsrael 2014, the fourth bi-annual conference & exhibition in March.  Over 1,200 nano-tech professionals are attending from over 36 countries. The exciting possibilities include ultra tiny storage systems, contact lens sensors for diabetics, protective clothing, water purification, renewable energy and super-fast computers.

We now travel on the high wire from the micro to the macro. Forty students at Herzliya High School have built a low-cost micro-satellite to be launched by Russia in April.  The 10cm cube will circle the Earth every 90 minutes and form part of a network of international satellites designed to provide a cell phone lifeline to travelers in remote areas.  Back in civilization, Israeli start-up Glove has an app to help mobile phone users select the network provider with the consistently best reception. 


Israeli technology is hard-wired into the core of most of today’s computers and mobile hardware.  Indeed it seems to be chips with everything, what with Israel’s Altair Semiconductor installing its 4G communications chipset in the new Google/HP Chromebooks.  The 4G chips access the Internet at ten times the speed of 3G chips.  You can even put a microchip from an Israeli start-up called Oggii on your dog to check if it’s healthy. Or you can boost the Wi-Fi signal to any laptop, tablet or smartphone with the unique “implicit beamforming” technology from Israel’s Wi-Fi chip manufacturer Celeno.

Rafael Advanced Defense Systems will definitely be beaming if its new Iron Beam system performs well at next month's Singapore Air Show. Iron Beam’s high-energy laser based air-defense system complements Iron Dome by intercepting very short-range rockets, mortar, and airborne target attacks.  Meanwhile, the UK’s Economist magazine gave rare praise to the Israeli whose research led to a radar system that helps avoid collisions – between aircraft and flocks of birds.  And you can watch the ultimate fly-by-wire video as Israel’s unmanned flying car completed its first fully automatic test flights.  The Air Mule Vertical Takeoff and Landing craft from Israel’s Tactical Robotics has great potential for use as an air ambulance.


I’ll finish by descending from the clouds to describe two contrasting Israeli innovations.  You can’t get more low-tech than a collapsible camping grill made from stainless steel wires.  Israeli Roee Magdassi (a student at the Bezalel Design Academy in Jerusalem) has designed the Stakes camping grill that folds up to the size of a paper towel when not in use.  His IDF service inspired him to make a lightweight alternative to the ones he had to carry in his army backpack.  Finally, the makers of the seven-dollar Israeli-developed Keepod “thumb drive” have launched the first project in their program to “computer-enable" some of the world’s 5 billion people who don’t have access to technology.  Via Crowdsourcing, you can wire some funds to help 1500 of Nairobi’s slum dwellers get on-line and have a new chance in life.

Stay wired in for more news of exciting Israeli innovations.

Michael Ordman writes a free weekly newsletter containing positive news stories about Israel.
For a free subscription, email a request to michael.goodnewsisrael@gmail.com

The Right Connections


 
According to Avishai Abrahami, founder of website builder Wix, Israeli start-ups have a surprising secret weapon - helpful connections with established companies, even competitors!  Israeli entrepreneurs regularly help newcomers, because these entrepreneurs originally received help themselves.  Nothing exists in isolation in the Jewish State and the theme of “connections” links all of the following recent news articles.

Israel has built links with top hospitals and medical institutions around the world.  Experts from Boston Medical Center trained Israeli surgeons at Rambam Medical Center in Haifa to use surgical robots to perform advanced pediatric surgery.  For the first time, they used Rambam’s da Vinci robot to correct congenital defects on Israeli children.


Israel’s Dr. Nizam Razack also connected with US surgeons and robots when he performed the world’s first robotic brain surgery.  At Celebration Health Hospital in Orlando, Florida. Dr Razack used the Renaissance robotic guidance system from Israel’s Mazor Robotics to perform successful deep brain stimulation (DBS) on a Parkinson’s sufferer.  In another US medical collaboration, researchers at Tel Aviv University and Chicago’s Northwestern University worked together to discover that a mutation in skin cell molecules disrupts the immune response and triggers allergic reactions.

Dr. Ayelet Erez used her connections from studying and working at the Technion, Sheba Medical Center, Tel Aviv University, Baylor College Texas and the Weizmann Institute to uncover the link between the enzyme ASL and Nitrous Oxide, which is essential for regulating blood pressure.  Meanwhile, Ariel Munitz of Tel Aviv University has discovered a link between cancer and white blood cells called macrophages.  A particular stimulus will make them heal cancer and fibrosis. But a different stimulus actually makes the condition worse.  But potentially Israel’s most important medical connections are contained in Israel’s "National Network of Excellence" (NNE) in Neuroscience.  Established by Israel’s Teva, NNE has just granted funds to 46 scientists at seven Israeli universities and teaching hospitals to boost therapeutic developments for Alzheimer’s, MS, dementia and other brain diseases.

Israelis are also very good at breaking unhelpful connections.  Why, for instance, do aerosols need to contain dangerous compressed gases and be stored in expensive, metallic, cylindrical containers?  Israeli startup GreenSpense has developed an eco-friendly system for dispensing liquid products. A thin elastic sleeve inside the product generates high pressure, which is released at a touch of a button.  Another connectivity problem is solved by Israeli start-up Pressy.  Sometimes you have to perform many laborious connected functions on your smartphone before you can take a photo, or order a pizza etc.  Pressy provides “one button to rule them all”, which you attach to the headphone socket of your android device.


Some important international connections were enhanced recently:
-         Chinese investment in Israeli biotech NasVax will boost development of treatments for fatty liver disease and Alzheimer’s. 
-         Israel Chemicals announced it is to mine phosphates in Vietnam.
-         Israel’s Ormat Industries completed a 100mW geothermal power plant in New Zealand.
-         The World Bank is investing in Israel’s Kaiima, developing resilient and high yield grain.
-         The world’s largest Muslim country, Indonesia, is to use Israeli technology to build roads.

Staying with the international connection, but on a lighter note, hundreds of Hungarians at the Israeli festival in Budapest satisfied their hunger on the largest bowl of Hummus that Hungary has ever seen.  And international sporting links included the signing by Scottish soccer champions Celtic of Israeli midfielder Nir Biton from FC Ashdod.  The 21-year-old will now connect up with fellow countryman, Beram Kayal who already plays for Celtic. 

It is inspiring that there is an Israeli connection at the top of so many International companies.  According to Bloomberg Rankings, graduates of Israel’s Technion Institute make up the seventh highest number of chief executives of the top technical companies in the USA.

To conclude, here are two news items that connect the modern Jewish State with its historical origins.  Firstly, it may have been the phenomenal number of recent ancient Biblical discoveries that persuaded Bar Ilan University archaeologists to purchase a $70,000 handheld X-Ray Florescent Spectrometer to go with the Fourier spectrometer already being used.  The two devices now provide Bar-Ilan with the best molecular analysis capabilities in the world.  And finally, can you imagine Miriam Siebenberg’s surprise when she uncovered connections going back 2,000 years in the form of an ancient Jewish residence underneath her Jerusalem home. As Miriam says of the Siebenberg House Museum, “Both my roots and the roots of our people are right underneath this house.”  It’s living history.

Stay connected for the next inspiring installment.

Michael Ordman writes a free weekly newsletter containing Good News stories about Israel.
For a free subscription, email a request to michael.goodnewsisrael@gmail.com