Showing posts with label chemotherapy. Show all posts
Showing posts with label chemotherapy. Show all posts

How Lucky is Israel?


Last week, Ben Gurion University researchers made an “accidental” discovery, when testing an experimental anti-inflammatory drug, that could signify a breakthrough in the treatment of deadly infections.  My immediate thought was how “lucky” the BGU scientists were - but in reality, the discovery followed the proscribed use of methodical testing procedures and meticulously careful observations.  Here are some further recent cases of where Israelis definitely do not rely on “luck” when it comes to vital innovations and activities.

Traditional cancer chemotherapies depend on the laws of chance in that sufficient numbers of cancer cells will be destroyed alongside the (unwanted) death of normal, healthy cells.  Several Israeli companies, however, are working on removing this random, “splatter-gun” approach.  One of these, Quiet Therapeutics, has developed the “GAGomer,” a new class of nano-particle that specifically targets tumors and blood cancers.  Another Israeli biotech, Compugen, has announced positive initial experimental results for two Antibody-Drug Conjugate (ADC) treatments.  ADC therapy uses antibodies to target proteins present at high levels in cancer cells, releasing a toxic payload to kill the cells.

Some say that those who inherit a high risk of cancer are simply “unlucky”.  That may indeed be the case, however with genetic screening, it no longer needs to be a question of luck as to whether the onset of cancer is detected and treated early enough to save their lives.  So it is fortunate that researchers at the Hadassah Medical Center in Jerusalem have discovered a genetic mutation that can identify those at risk of colon and uterine cancers.  Similarly, doctors and researchers no longer need to rely on luck when examining patients for the early onset of Parkinson’s disease.  Patients can now be monitored continuously, using smart watches linked to smartphones. The data is then transmitted to an advanced analytics platform developed by Intel Israel that can handle 300 observations per second from each patient.

https://www.youtube.com/watch?v=OJX9f8goIq8#t=139 

On a Syrian street, a 23-year-old man was unfortunate to have been hit by a bullet that shattered his lower jaw and blew his teeth to bits.  Luckily for him, he was rushed across the Israeli border and taken to Haifa’s Rambam hospital where doctors implanted a custom-made 3D-printed titanium jaw in a pioneering operation. One day after surgery, the patient was eating and speaking.  Meanwhile, a Palestinian Arab baby with heart problems suffered a heart attack whilst on his way to Jordan for treatment.  Luckily for him, IDF medics arrived to resuscitate him and evacuated him and his grateful parents to Jerusalem’s Hadassah hospital.

https://www.youtube.com/watch?v=EQvH5Saw5ZA 

Many Israeli children were “lucky” to enjoy a couple of days playing in the snow that fell across the country.  Following a request by the Palestinian Authority, the IDF have been helping to clear snow blocking roads to the PA city of Ramallah, helping to clear flooding in Tulkarem and pushing a not-so-lucky Palestinian Arab taxi driver out of frozen mud.  Overseas, the Philippines has been very unlucky with the weather, as typhoon Hagupit (Ruby) has just devastated a country still reeling from last year’s typhoon Haiyan.  Luckily, an IsraAID emergency response team has again responded quickly with medical relief and humanitarian aid.

Anyone unlucky enough to have lost their water supply due to a burst water main will appreciate the monitoring systems from Israel’s TaKaDu.  The water utilities that have engaged TaKaDu’s services don’t wait for a lucky phone call from a dutiful member of the public and instead are saving billions of liters of water otherwise lost through leaking pipes.

https://www.youtube.com/watch?v=SDsmIhhmE3U 

Having proved that Israelis don’t rely on luck, I will conclude with two recent news stories where fortune (or something else) must have been involved.  First, it was lucky that art historian Nirit Shalev-Khalifa stopped to answer her cell phone when she was driving away from Jerusalem.  The tour guide that called her had just happened to be visiting Jerusalem’s Ades “Great” Synagogue and seen someone begin some very amateurish restoration work.  Nirit made a quick “U” turn, just in time to save the Stark Murals – an early 20th Century masterpiece of Jerusalem’s Syrian Jewry.

Finally, a baby faun in Hebron had a lucky escape from being eaten by poachers.  Israeli police were busy uncovering a weapons and drugs cache when they heard noises coming from inside a barrel.  Instead of dismissing the noise as just rats, they checked the barrel and found the faun (a protected species in Israel) chained up inside it.  The faun was transferred to the Jerusalem Biblical Zoo for medical treatment.

Put your trust in Israeli ingenuity - you won’t believe your luck.

Michael Ordman writes a free weekly newsletter containing positive news stories about Israel.
For a free subscription, email a request to michael.goodnewsisrael@gmail.com

Israel begins a New Year


The Jewish New Year is a time of exciting new beginnings, and there is no better place to observe them than in the Jewish State itself.

Israeli medical discoveries and advances are announced every week, but the impact of the most recent innovations is simply staggering.  Technion scientists are the first in the world to manufacture cancer-killing chemicals inside the tumor itself.  These directly target the tumor, fooling the cancer’s defense mechanisms and avoiding the usual harsh side effects of chemotherapy.  Over at the Hebrew University of Jerusalem, Yotam Bar-On has developed new antibodies to attack the flu virus.  These antibodies disrupt virus’s ability to evade the immune system’s natural killer cells.

At Jerusalem’s Shaare Zedek Medical Center, a cutting-edge brain catheterization procedure was broadcast live to thousands of doctors attending the world’s largest cardiovascular conference in Washington DC.  And at the same hospital, doctors have begun using a robot to unblock arteries remotely.  The robot is more accurate than human hands and avoids any radiation risk to surgeons.  The robot is manufactured by Corindus – founded by two Israeli scientists.




Further new Israeli treatments include the bladder cancer product BC-819, developed by Israel’s Biocancell Therapeutics, which has just completed a successful clinical trial.  Meanwhile, in Hong Kong, sufferers of severe Glaucoma will now be able to receive treatment using the innovative CO2 laser IOPtiMate manufactured by Israel’s XLVision Sciences.  Finally, scientists at the Hebrew University of Jerusalem have developed a new cocktail of genes that are extremely effective in turning adult cells back into stem cells. These stem cells, when transplanted, can renew previously damaged tissue or organs.

The New Year will see the culmination of hundreds of new Israeli technological ventures.  Israel will build its first bio-waste power plant at Neot Hovav in the Negev that will generate 5 megawatts of clean energy and process over one hundred thousand tons of organic waste per year.  A new National Photonics and Electro-Optics Research Center will allow professionals and students to delve into the exciting new science of light and optics. 

The Israeli government will establish a new hi-tech authority - the National Technical Innovation Authority - to enhance Israeli innovation and bolster economic growth. And Israel’s Algatechnologies is to build a new factory at Kibbutz Ketura that will grow new forms of beneficial micro-algae for use in foods, medicines and cosmetics. 



The New Year promises to enhance relationships between the Jewish State and other forward-thinking countries.  “The sky’s the limit” when it comes to new ties between Israel and India, as Israel’s Prime Minister stated at his meeting with his Indian counterpart, Narendra Modi in New York.  Israel’s Economic Office in Delhi has already been busy matchmaking Israeli and Indian companies.  Even a well-established relationship was strengthened when the US Senate unanimously adopted the United States-Israel Strategic Partnership Act that will lay the foundation for expanded US-Israel cooperation in defense, energy, agriculture, and other key sectors. 

We can only wish that future Israeli-Arab relations mirrored the words of exiled Syrian opposition leader Dr. Kamal Al-Labwani, who visited wounded Syrians being treated at Israel’s Ziv Hospital. "This moving humanitarian gesture is an opening for rapprochement between the two peoples and hope for peace on quieter days," he said.  And if other Arab leaders visited Israeli hospitals, such as Haifa’s Rambam Medical Center, they would see young Israeli patients start the school year.  Jews, Moslems, Christians, Druze, plus Arabs from Gaza - all study together in their year groups.  And whilst we are dreaming of new beginnings, listen to the “Dream it. Do it” New Year message from the students of Israel’s Technion – in 14 languages.



Finally, there is no better way to start a new year than by starting a new life.  24,800 new immigrants to Israel did precisely that in the last 12 months - a 28% increase on the previous year and the highest number in the past five years.  For the first time in history, more immigrants arrived from France (nearly 6,000) than from any other country, and many more are expected in 5775.  An even larger number of new arrivals had far less distance to travel. A record 176,230 Israeli babies were born in 5774 - the next generation of new beginnings.

Happy New Year.

Michael Ordman writes a free weekly newsletter containing positive news stories about Israel.
For a free subscription, email a request to michael.goodnewsisrael@gmail.com

The Value of Life



My instinctive reaction to Monday’s tragic news was to not write a positive news blog this week.  But why let the terrorists win?  Dry Bones’ cartoon included the line “... we find joy in remembering their lives ...” and Israelis’ love for human life needs to be emphasized even more at this time.

There was positive news recently for three Israeli organizations producing devices to detect early-stage cancer.  First, Israeli biotech Nucleix raised more than $5 million to finance its diagnostic test for early detection of bladder cancer and possibly also colon, lung and prostate cancers.  Secondly, the NaNose cancer detector invented by Israel Technion Institute’s Dr Hossam Haick is now ready to be marketed and has been licensed to Boston’s Alpha Szenszor.  NaNose diagnoses early-stage malignant tumors by analyzing exhaled breath.  Finally, the numbers of tests performed by the MarginProbe breast cancer scanner, developed by Israel’s Dune Medical, have now passed the 1000 mark since the device was launched in 2013.  MarginProbe confirms that the entire malignant tumor has been removed, before the surgeon finishes the operation.




Haifa’s Technion Institute is also one of Israel’s centers for development of treatments to eradicate cancer altogether.  Technion researchers recently discovered that visible and UV light destroys cancer’s resistance to chemotherapy.  Almost simultaneously, a parallel group of Technion researchers teamed up with others at Germany’s Max Planck Institute to develop minute propellers, with the potential to deliver cancer-killing chemicals directly to tumors without harming healthy cells.

Israel’s cardiologists continue to save lives – and not just Jewish lives. Two Druse brothers from the village of Hurfeish contracted the same genetic disease that weakens the cardiac muscle.  Doctors at Israel’s Schneider Children’s Medical Center transplanted a new heart into Rani in 2011 and have just successfully completed another heart transplant for his brother Dani.  And since the time that Israel’s three teenagers were abducted, Israeli doctors at Save a Child’s Heart (SACH) have saved five Palestinian Arab children at the Wolfson Medical Center in Holon.  Dr. Lior Sasson, SACH chief surgeon said, “children from both sides, shouldn’t be a part of the conflict.”

Israeli cardiovascular devices are an essential component of today’s life-saving medical technology.  Israel’s Itamar Medical manufactures the EndoPAT diagnostic device that measures how well your arteries are working.  Japan’s Nihon Kohden has just announced that it will market EndoPAT to 100,000 doctors in Japan as its flagship product for monitoring the heart and blood vessels.




It is also imperative to have a decent quality of life. Israel’s D-Pharm has obtained fast track status from the China's Food and Drug Administration (CFDA) for its DP-VPA epilepsy treatment.  Israeli biotech Intec has announced that its Accordion Levodopa treatment for Parkinson’s disease has met all its safety trial endpoints so that Phase 3 trials on Parkinson’s sufferers can now commence.  Israel’s BrainStorm reported positive interim results of Phase IIa trials of its “NurOwn” stem cell ALS therapy. And two wound clinics at Israeli health organization Maccabi will treat patients with chronic leg ulcers using Vergenix gel developed by Israel’s CollPlant. Vergenix is based on CollPlant’s plant-based collagen.

Financial assistance and expert advice is available to Israeli start-ups if they are saving or improving lives.  Jerusalem NGO Pretense’s A3i (Accelerating Inclusion In Israel) is the world’s first support incubator, exclusively for startups developing products and services for people with special needs. A3i currently supports 13 Israeli companies. Philips and Teva’s new joint support incubator Inspire Healthcare Innovations Ltd will invest in start-ups developing treatments and medical devices.  US pharmaceutical giant Merck will work with Israeli companies on projects researching into life-saving medicines and will match Israel’s financial support to those companies.  Finally, Israel’s Trendlines received the “Best Incubator” award from Israel’s Office of the Chief Scientist. One of Trendlines supported companies, MitrAssist, received Best Start-Up of the Year for its device to treat faulty heart valves.




To conclude, here are two recent news items that should be an inspiration to everyone that loves life.  Two scientists at Israel’s Weizmann Institute have been selected by the prestigious medical journal Cell for their “40 under 40” list of young world-leading scientists in their field. One of them, Jacob Hanna, is an Israeli-Arab.  His breakthroughs will advance the possibility of the future medical use of stem cells as “spare parts” for damaged cells and tissues.  Jacob comes from a family of doctors. His role model is his uncle Dr Nabil Hanna who developed Rituxan, the first monoclonal antibody approved for the treatment of non-Hodgkin's lymphoma.

Finally, it’s not the $25 million donation that Sheldon and Miriam Adelson donated to develop the medical school at Ariel University that attracted my attention.  It is the fact that the Adelsons were inspired to action after the abduction of the three Israeli teenagers.  As Sheldon poignantly stated, “the medical studies at Ariel University underscore humanity, the desire for life and the value of human life wherever they are.”

I wish the families of the three boys Long Life.

Michael Ordman writes a free weekly newsletter containing positive news stories about Israel.
For a free subscription, email a request to michael.goodnewsisrael@gmail.com

It Happened Here First



You probably already know about the most famous of Israeli “firsts”. Such as Intel’s microchip breakthroughs, SMS technology, the digestible camera and cherry tomatoes.  But every week there is news of exciting discoveries and innovations from the Jewish State. Last week, there was even more than usual.

Dr. Itai Amir of Israel’s Maayanei Hayeshua hospital discovered a new strain of bacteria when examining a patient’s blood culture. The microorganism – named Eisenbergiella Tayi - assists in digestion and has attracted major scientific interest.  And in another discovery, Hebrew University of Jerusalem researchers have identified the cause of the dreadful intestinal inflammation side effects of chemotherapy.  The scientists isolated the protein Interleukin-1 (IL-1 beta), and are confident that its effects can be blocked.

Three “first of their kind” Israeli medical devices were in the news recently.  Israel’s BioControl Medical has developed the first device to treat chronic heart failure using neuro-stimulation.  It works by stimulating the vagus nerve on the right side of the neck. Trials are currently being conducted at 80 medical centers in the US, Europe and Israel.  Next, CerOx from Israel’s Ornim is the first and only non-invasive device on the market monitoring blood flow to the brain in patients with severe brain trauma.  It uses ultrasound and near-infrared light to measure oxygen saturation and prevent brain damage.  But pride of place goes to Israel’s Brainsway, which has launched a new era in the treatment of brain disorders such as Parkinson’s and Schizophrenia. Brainsway’s Deep Brain Transcranial Magnetic Stimulation (TMS) has also received CE approval to treat depression and its systems have just been installed at Stockholm's Karolinska University Hospital.  Sweden has one of the highest rates of depression in the world.



Israel is always the first to respond to international humanitarian disasters such as in Haiti and the Philippines.  But it has also become the first State that countries call on to request all sorts of assistance.  For example, a team of Israeli scientists has just gone to Bhubaneswar in India, to test a pilot program called “phyto-remediation” that uses plants to remove pollutants from contaminated wetlands.  In another venture, Israel and Germany are launching “The Africa initiative" - a joint project for humanitarian relief in those developing countries.  And the Greek charity Bouroume has made its first visit to Israel to see how Leket Israel organizes 50,000 volunteers to pick, rescue and distribute fresh produce to the needy.  No wonder 170 countries nominated Israeli Ambassador to the UN, Ron Prosor, for his first role since Israel joined a UN Human Rights group.  Ambassador Prosor was chosen to run the elections for the UN Human Rights Committee!

When Israeli cleantech company Energy Industries is called on to implement environmentally friendly energy solutions for its customers it always looks first for local natural resources.  So in Ghana it extracts methane from a local landfill site, and in Georgia, hot springs are used to power greenhouses.  Over in California, the 392-megawatt concentrating solar power (CSP) plant built by Israel’s BrightSource Energy has commenced operations.  The five-square-mile Ivanpah solar energy generating system in the Mojave Desert is generating nearly 30 percent of all of the US’s solar power.  It has even inspired a pop music album – and that must be a first for a solar power station.



Three new Israeli innovations provide “first-contact” alternatives for computer users.  You can use the gesture technology from Pointgrab and become one of the first to operate your Lenovo computer from up to two meters away, even in low light conditions.  Or obtain a first-class degree by using the N-trig active pen to write over electronic lecture notes on your Intel Educational Tablet. But first prize must go to the UpSense Super Keyboards from Israel’s Inpris.  They are the first-ever invisible keyboards to enable fast typing by either blind or fully sighted users.  You can even help finance their launch and be the first to receive one.



Before you answer any accusation that Israel always puts its Jewish citizens first, first read my weekly newsletter.  Every week it contains news stories about Israel’s minorities, such as the Israel Education Ministry’s national program to encourage Arab children to read at home.  Maktabat al-Fanoos (“Lantern Library”) will deliver 4 first-stage books free to over 45,000 children at 1,750 pre-school kindergartens in Arab communities.  Over the border, Jordan is the first foreign country to purchase supplies of Israel’s new natural gas deposits.  And one year after Israel first started treating Syrians wounded in their civil war, Israeli doctors at Rambam Medical Center discharged a six-year-old Syrian boy who had first arrived six weeks earlier in a coma. His father was overjoyed, as his son was the last surviving member of his family.

Not for the first time, I’ll finish with an animal story.  Achziv is the first ever beach on Israel’s Northern Mediterranean coast to be declared an internationally recognized protected dolphin habitat.  Achziv offers deep waters for the dolphins to feed in.  I suspect, however, that these intelligent creatures are not the first to recognize that the Jewish State is a safe haven from troubled waters.

Please spread the word about Israeli innovation.

And remember - you read it here first!

Michael Ordman writes a free weekly newsletter containing positive news stories about Israel.
For a free subscription, email a request to michael.goodnewsisrael@gmail.com

Three weeks? Yes just Three weeks



During the last three weeks, I published three blogs (here, here and here) that rubbished the Israel BDS (Boycott, Divestment and Sanctions) idiots who insist on shooting themselves in the foot by refusing any of Israel’s medical innovations.  I have just looked back at what Israelis have been working on in all areas over the last three weeks and I can hardly believe that so much has been achieved.  So let me bring you up to date on just the medical and clean technology advances.

In medical news, we heard that the technique treating cancer conceived 30 years ago by Weizmann’s Zelig Eshhar is now curing patients across the USA.  Other related Israeli innovations include:
-         A medication to prevent women’s ovaries being damaged during chemotherapy.
-         A new probe with two cameras that can detect cancerous polyps in the colon.
-         A derivative of an Israeli mushroom that appears to be effective against pancreatic cancer.

Concerning the brain:
-         Tel Aviv University researchers have invented a gel and implant to repair damaged nerves
-         Ben Gurion University’s future CARES center will boost its top research into stress-related illness.
-         Israel’s Reuth Center is using a computerized shoe to teach people with brain damage how to walk again. 


Heart-warming news includes:
-         Discovery at Hadassah Medical Center of an area of the body that can grow new heart muscle tissue. 
-         An implant under development at Israel’s MitrAssist that will fix a leaky heart mitral valve.

Recent successful heart operations include:
-         Rebuilding the chest to protect the exposed heart of a baby born without a breastbone.
-         Performing a heart transplant on a 28-year-old Israeli-Arab – the oldest patient at a children’s hospital.
-         Save A Child’s Heart doctors saved the life of a 4-year-old Syrian girl born with only one ventricle.

In medical research:
-         Israeli biotech Cell Cure received a government grant to help develop its macular degeneration treatment.
-         Scientists at the Israel’s Technion have constructed an advanced biological computer.
-         Life Science guru Dr Ido Bachelet demonstrated what Israel’s microscopic robots can do.


In Agro-technology, Israel has been innovating in order to benefit the world
-         Israel’s Volcani Center has developed processes to keep fruit and vegetables fresh for months.
-         Israeli firm Indolive is helping farmers to grow olives in the deserts of western India.
-         Israeli start-up TIPA are expanding production of their environmentally-friendly food packaging.
-         And the Hebrew University’s ran an International Symposium on balancing technical progress with health.

In Water technology:
-         Israel’s Netafim, the pioneer of drip irrigation, won the 2013 Stockholm Industry Water Award.
-         UK’s Anglia Water has bought an advanced sewage treatment system from Israel’s Mapal
-         23 Israeli companies presented their innovative water products at “Wasser Berlin”
-         IBM Israel announced new software to interpret utility meter readings and sensors and detect water leaks.
-         And the Israeli water authority has opened the Degania Dam to replenish the flow of the Jordan River.

On the energy front:
-         The Israeli government is subsidizing the replacement of electric water heaters to solar powered systems.
-         1.8 trillion cubic feet of natural gas has been discovered at the Karish prospect in Israeli territorial waters.

In approximately three weeks time, we will enter a sad period of the Jewish calendar known as “the three weeks”. Jewish tradition says that the last day of the three weeks will one day turn into a festival of celebration and usher in a new age of prosperity and peace.

I can’t wait.

Michael Ordman writes a free weekly newsletter containing Good News stories about Israel.
For a free subscription, email a request to michael.goodnewsisrael@gmail.com